Deputies said Charles Guffey was last seen by his wife at their residence on Saturday. He had cell phone contact with family members around 3 p.m. Sunday and was in the area of State Road 29 in Golden Gate Estates.
Deputies said Guffey is described as white, 5 feet 10 inches tall and 140 pounds with brown hair and blue eyes.
He may be driving a tan Nissan four-door passenger vehicle with the Florida license plate number K969SD.
Guffey is on medication and may become disoriented without taking it.
Anyone with information is asked to call the Collier County Sheriff's Office at 252-9300.